Research Journal of Pharmacy and Technology

S. Gomathi ¹, R. Shanmuga Sundaram ², M. Vijayabaskaran ¹, C. Kannan ³, R. Sambathkumar ³

Affiliations
1 Department of Pharmaceutical Chemistry, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
2 Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
3 Department of Pharmaceutics, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN

Abstract

Background: Studies of antioxidant substances in foods and natural products have gained increasing interest. The prevalence of neurodegenerative diseases are increasing globally. Effective treatment is necessary to minimize the neuronal damage and oxidative stress. Traditional medicines offer potent pharmacological activity with minimal side effects compared to synthetic drugs to treat such chronic disorders. Objective: The present study was aimed to evaluate the neuroprotective effect of ethanol extract of Pedalium murex Linn. (EEPM) leaves against lipopolysaccharide (LPS)-induced endotoxemia. Materials and Methods: Neurodegeneration was induced in rats with a single intraperitoneal injection of LPS (1 mg/kg). The neuroprotective activity was investigated following LPS-induced endotoxemia and then subjecting the animals to a battery of behavioural tests such as open field test (OFT), elevated plus-maze (EPM) and forced swim test (FST) to test anxiety and depression. At the end of the study, rats were sacrificed, brain hippocampal region was isolated and biochemical parameters were analysed. Results: These results highlight the neuroprotective potential of EEPM in LPS-induced anxiety and depressive illness model which may be partially due to inhibition of oxidative stress-neuroinflammatory cascade. Conclusion: The present study proved that EEPM has promising anti-anxiety, antidepressant action and can be potential candidates for the management of LPS-induced neurodegeneration.

Keywords

Anxiety, Depression, Lipopolysaccharide, Oxidative Stress, Neuroprotection.

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S. M. Vanmathi ¹, M. Monitha Star ¹, R. Shanmuga Sundaram ², M. I. Jishala ¹

Affiliations
1 Department of Pharmacy Practice, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN
2 Department of Pharmacology, JKK Nattraja College of Pharmacy, Komarapalayam, Namakkal (Dist), Tamil Nadu - 638183, IN

Abstract

Type 2 Diabetes mellitus (DM) is a common metabolic disorder characterized by hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. The term Metabolic Syndrome describes the clustering of these conditions. The lipid abnormalities are prevalent in DM because insulin resistance or deficiency affects key enzymes and pathways in lipid metabolism. The altered metabolisms of carbohydrate, lipid and protein play a role in diabetic complications like hypercholesterolemia and hypertriglyceridemia, because of this hyperlipidemia in type 2 DM having the diabetic complication. The traditional risk factors that are associated with coronary artery disease (CAD) in the general population including obesity, physical inactivity, hypertension (HT), and dyslipidemia are prevalent in the diabetic population. Persons with diabetes tend to have a clustering of these risk factors in what is termed the metabolic syndrome hence multiplying their overall risk. Obesity increases the risk of CAD in adults and has been strongly associated with insulin resistance in normoglycemic persons and in individuals with type 2 DM.

Keywords

Diabetes Mellitus, Hypertension, Coronary Artery Disease, Obesity, Macro Vascular Complication.

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